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Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat
07:46

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus (MRSA) in Rat

Published on: June 4, 2012

Agents for the Treatment of Multidrug-resistant Gram-positive Endocarditis

Jennifer K Long1

  • 1The Cleveland Clinic Foundation, Department of Pharmacy, 9500 Euclid Avenue, Cleveland, OH 44195, USA. longj@ccf.org.

Current Infectious Disease Reports
|June 21, 2005
PubMed

Insights

Newer antibiotics show promise against multidrug-resistant gram-positive infections, including methicillin-resistant staphylococci and vancomycin-resistant enterococci. However, more research is needed to confirm their effectiveness in treating conditions like endocarditis.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Emerging resistance in gram-positive pathogens necessitates novel therapeutic agents.
  • Multidrug-resistant organisms like methicillin-resistant staphylococci and vancomycin-resistant enterococci pose significant clinical challenges.

Purpose of the Study:

  • To review newer antimicrobial agents with activity against multidrug-resistant gram-positive pathogens.
  • To evaluate the potential utility of these agents in treating serious infections.

Main Methods:

  • Literature review of in vitro and clinical data for newer antimicrobial agents.
  • Analysis of antimicrobial activity against key resistant pathogens.
  • Assessment of available clinical evidence for specific infections.

Main Results:

  • Several newer agents demonstrate in vitro and clinical activity against target pathogens.
  • Daptomycin exhibits rapid bactericidal effects; linezolid and quinupristin/dalfopristin are bactericidal against staphylococci.
  • Limited clinical data exist for the use of these agents in endocarditis.

Conclusions:

  • Newer agents offer potential treatment options for multidrug-resistant gram-positive infections.
  • Further clinical investigation, including combination therapies, is required to establish definitive treatment guidelines for complex infections such as endocarditis.

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