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Cardiovascular and Endothelial Disease in HIV Infection

Michelle S Cespedes1, Judith A Aberg

  • 1New York University, AIDS Clinical Trial Unit, 550 First Avenue, C & D Building, Room 558, New York, NY 10016, USA. michelle.cespedes@med.nyu.edu.

Current Infectious Disease Reports
|June 21, 2005
PubMed

Insights

Combination antiretroviral therapy improves HIV outcomes but may increase cardiovascular disease risk due to metabolic complications. This review examines HIV

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Endocrinology

Background:

  • Combination antiretroviral therapy (cART) has improved outcomes for HIV-infected patients.
  • Metabolic complications, including insulin resistance, dyslipidemia, and truncal adiposity, are prevalent with cART.
  • These metabolic changes raise concerns about premature cardiovascular disease (CVD) risk in HIV patients.

Purpose of the Study:

  • To review current data on the impact of HIV and cART on cardiovascular health.
  • To update the understanding of cardiovascular event risk in the HIV-infected population.

Main Methods:

  • Literature review of recent data.
  • Analysis of effects on endothelial dysfunction, serum biomarkers, and vascular indices.

Main Results:

  • HIV and its treatment can affect endothelial function.
  • Specific serum biomarkers and vascular indices are altered in HIV-infected individuals.
  • The review synthesizes current evidence on premature CVD risk.

Conclusions:

  • Metabolic complications associated with HIV treatment warrant attention regarding cardiovascular risk.
  • Further research and monitoring are needed to mitigate long-term adverse events and cardiovascular risk in HIV patients.

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