Related Experiment Video
Updated: Aug 17, 2026

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis
Fatemehsadat Esteghamat1, Babak Noorinayer, Mohammad Hossein Sanati
1Research Center for Gastroenterology and Liver Disease, 7th floor, Taleghani Hospital, Tabnak St., Evin, P.O. Box 19835-178, Tehran, Iran; Khatam University, Tehran, Iran.
Unlabelled:
Autoimmune hepatitis (AIH) is a rare frequent, multiplex disorder with undefined etiology. Susceptibility to autoimmune hepatitis results from complex interactions between genetic and environmental factors. In this study, we investigated the involvement of C77G mutation in CD45 gene in patients with autoimmune hepatitis among Iranian population by genotyping this mutation in 70 patients and 140 healthy individuals.
Methods:
: After amplifying exon 4 by Polymerase chain reaction, we genotyped this mutation with MspI restriction endonuclease among the studied population.
Results:
: None of the cases with AIH was hetero or homozygote for C77G mutation. Controls had normal genotype except one of them who was heterozygote for C77G mutation.
Conclusion:
: Our results do not confirm the genetic link between C77G mutation and autoimmune hepatitis in Iranian population.
Related Concept Videos
Hepatitis
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Type I Diabetes I: Introduction

