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Association Between Dietary Advanced Glycation End Products (AGEs) and Pancreatic Fat Accumulation: Evidence From a
Mohammad Reza Shahparvari1, Zahra Yari2, Maedeh Chegini1
1Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Endocrinology, Diabetes & Metabolism
|June 3, 2026
Summary
Higher dietary intake of Advanced Glycation End Products (AGEs) is linked to an increased likelihood of pancreatic steatosis (PS). Reducing dietary AGEs may benefit pancreatic fat accumulation, but more research is needed.
Area of Science:
- Metabolic health
- Nutritional science
- Gastroenterology
Background:
- Pancreatic steatosis (PS) is a metabolic condition linked to obesity and insulin resistance.
- Advanced Glycation End Products (AGEs) are found in processed foods and associated with metabolic disorders.
- The relationship between dietary AGEs and PS has not been previously studied.
Purpose of the Study:
- To investigate the association between dietary Advanced Glycation End Products (AGEs) intake and pancreatic steatosis (PS).
Main Methods:
- A case-control study involving 278 individuals with gallstones, classified as having PS (n=89) or not (n=189).
- Dietary intake was assessed using food frequency questionnaires.
- Logistic regression models were used to analyze the association between dietary AGE intake quartiles and PS, adjusting for confounders.
Main Results:
- Higher dietary AGE intake was significantly associated with an increased likelihood of PS.
- After full adjustment, individuals in the third and fourth quartiles of dietary AGE intake had significantly higher odds of PS compared to the lowest quartile (OR=2.76 and OR=3.3, respectively).
- A significant positive trend was observed in the odds of PS across increasing quartiles of dietary AGE intake (p=0.024).
Conclusions:
- Dietary AGEs may play a role in pancreatic fat accumulation.
- Causality cannot be inferred from this study.
- Further prospective and interventional studies are required to confirm the association and explore the impact of reducing dietary AGE exposure on pancreatic fat.
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