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Updated: Feb 20, 2026
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
10.3K
GM-CSF gene-transduced tumor vaccines
Robert Eager1, John Nemunaitis
1Mary Crowley Medical Research Center/Texas Oncology PA, Dallas, TX 75201, USA.
Abstract:
GVAX is a GM-CSF gene-transduced tumor vaccine. Expression of the GM-CSF gene within either autologous or allogeneic tumor cell populations has demonstrated evidence of immune stimulation in patients and evidence of antitumor activity particularly in prostate cancer and non-small-cell lung cancer. Results of preclinical studies justify clinical investigation. A summary of clinical results is presented.
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