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Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
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[Disseminated fusarium infection in two neutropenic children]

A Petit1, M D Tabone, D Moissenet

  • 1Service d'hématologie et d'oncologie pédiatrique, hôpital d'enfants Armand-Trousseau, Assistance-publique-Hôpitaux de Paris, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|June 21, 2005
PubMed

Insights

Disseminated fusariosis is a severe fungal infection in children. Voriconazole shows promise as an alternative treatment to amphotericin B for this rare condition.

Area of Science:

  • Mycology
  • Pediatric Oncology
  • Infectious Diseases

Background:

  • Disseminated fusariosis is a rare, life-threatening fungal infection primarily affecting immunocompromised children, particularly those with hematologic malignancies or post-bone marrow transplant.
  • Treatment challenges and high mortality rates (50-70% in adults) underscore the need for effective therapeutic strategies.

Observation:

  • Two pediatric cases of disseminated fusariosis are presented: one fatal case in a boy with relapsed acute lymphoblastic leukemia despite amphotericin B treatment.
  • A second case in a girl with acute myeloid leukemia showed treatment failure with amphotericin B but achieved recovery with voriconazole and resolution of neutropenia.

Findings:

  • Voriconazole demonstrated efficacy in a pediatric case of disseminated fusariosis unresponsive to amphotericin B.
  • The patient receiving voriconazole experienced disease remission and tolerated secondary prophylaxis during subsequent leukemia relapse treatment.

Implications:

  • Voriconazole represents a potential alternative antifungal agent for managing disseminated fusariosis in pediatric patients.
  • Its use, both for acute treatment and secondary prophylaxis, warrants further investigation in this vulnerable population.
Abstract

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