Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Foamy transformed Gaucher cells.

M Elleder1

  • 1Hlava's First Institute of Pathology, First Medical Faculty, Charles University, Prague, CSFR.

Zentralblatt Fur Pathologie
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Prenatal diagnosis of lysosomal enzymopathies in the Czech Republic].

Casopis lekaru ceskych·2012
Same author

[The role of PET-CT in decision making on the treatment of localized nodular form of pulmonary AL-amyloidosis].

Vnitrni lekarstvi·2012
Same author

Danon disease: a focus on processing of the novel LAMP2 mutation and comments on the beneficial use of peripheral white blood cells in the diagnosis of LAMP2 deficiency.

Gene·2012
Same author

Clinical and molecular characterization of a family with a dominant renin gene mutation and response to treatment with fludrocortisone.

Clinical nephrology·2010
Same author

Expression and lysosomal targeting of CLN7, a major facilitator superfamily transporter associated with variant late-infantile neuronal ceroid lipofuscinosis.

Human molecular genetics·2010
Same author

Oligodendroglia from ADSL-deficient patient produce SAICAribotide and SAMP.

Molecular genetics and metabolism·2010
Same journal

[Simultaneous occurrence of medullary and papillary carcinoma in the same thyroid lobe].

Zentralblatt fur Pathologie·1995
Same journal

[Xanthoid corpuscles in the cytoplasm of rat kidney tubule epithelium].

Zentralblatt fur Pathologie·1995
Same journal

Brain stem gliosis in the victims of sudden infant death syndrome (SIDS): a sign of retarded maturation?

Zentralblatt fur Pathologie·1995
Same journal

Sinusoidal changes in extratumoral liver tissue. Report of a case of metastatic liver small cell carcinoma with collagen IV detection and ultrastructural studies.

Zentralblatt fur Pathologie·1995
Same journal

The fine structure of normal and ectopic (tubal) human placental villi as revealed by scanning and transmission electron microscopy.

Zentralblatt fur Pathologie·1995
Same journal

Ultrastructure of composite tumours consisting of giant cell fibroblastoma and dermatofibrosarcoma protuberans.

Zentralblatt fur Pathologie·1995
See all related articles

Gaucher cells in Gaucher disease (Types I and III) can transform into foam cells, potentially complicating diagnosis in liver biopsies. This transformation involves lysosomal distension and reduced enzyme activity.

Area of Science:

  • Pathology
  • Cell Biology
  • Biochemistry

Background:

  • Gaucher disease is a lysosomal storage disorder.
  • Gaucher cells (GC) are characteristic storage cells in Gaucher disease.
  • Microscopic identification of GC is crucial for diagnosis.

Observation:

  • Two cases of Gaucher disease (Types I and III) exhibited extensive vacuolization of storage cells.
  • These cells transformed into non-specific foam cells in the liver and adrenal cortex.
  • The transformation involved significant lysosomal distension with lipid tubules and cytoplasmic reduction.

Findings:

  • Histochemical enzyme activities typically high in Gaucher cells were decreased or absent.
  • The foamy transformation of Gaucher cells can mimic other conditions.

Related Experiment Videos

  • This cellular change poses diagnostic challenges, particularly in liver biopsy interpretation.

    • Implications:

    • The study highlights a potential diagnostic pitfall in Gaucher disease pathology.
    • Understanding this cellular transformation is vital for accurate histopathological diagnosis.
    • Further research may clarify the mechanisms and diagnostic markers for this variant GC morphology.