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Laryngeal thrush.

Lucian Sulica1

  • 1Department of Otolaryngology, Beth Israel Medical Center, New York, New York 10003, USA.

The Annals of Otology, Rhinology, and Laryngology
|June 22, 2005
PubMed
Summary
This summary is machine-generated.

Laryngeal thrush, a fungal infection of the voice box, is often misdiagnosed, leading to delayed treatment. Early recognition and antifungal medication are key for effective management of this rare condition.

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Area of Science:

  • Otolaryngology
  • Mycology
  • Infectious Diseases

Background:

  • Superficial fungal infections (thrush) primarily affect mucous membranes.
  • Laryngeal candidiasis is infrequently reported and clinically underrecognized.
  • Delayed diagnosis and ineffective treatments are common, sometimes leading to unnecessary surgery.

Purpose of the Study:

  • To present cases of isolated laryngeal thrush without oral involvement.
  • To describe clinical features, predisposing factors, and treatment outcomes.
  • To compare findings with existing literature on laryngeal candidiasis.

Main Methods:

  • Retrospective case series of eight patients with isolated laryngeal thrush.
  • Review of clinical data, including symptoms, causative factors, and treatment.

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  • Comparison with 14 previously reported cases from the literature.

    • Main Results:

    • Hoarseness was a consistent symptom; dysphagia and odynophagia were absent.
    • Common predisposing factors included inhaled steroids (5/8 cases), systemic steroids, antibiotics, diabetes, and neutropenia.
    • Diagnosis was delayed by an average of 6 months; three patients had avoidable surgeries.

    Conclusions:

    • Isolated laryngeal thrush requires clinical suspicion, especially in patients with risk factors.
    • Inhaled corticosteroids are a significant risk factor, particularly for vocal fold candidiasis.
    • Prompt diagnosis and oral fluconazole treatment are effective, preventing complications.