Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Linear insertion of the atrioventricular valves without defect].

C Fredouille1, N Baschet, J E Morice

  • 1Unité de foetopathologie, service d'anatomie pathologique et de neuropathologie, CHU Timone, hôpital de la Timone, Marseille. catherine.fredouille@mail.ap-hm.fr

Archives Des Maladies Du Coeur Et Des Vaisseaux
|June 22, 2005
PubMed
Summary

A new study on fetal hearts with Down syndrome (trisomy 21) reveals a common minor cardiac anomaly: linear atrioventricular valve insertion without septal defects. This finding suggests a spectrum of atrioventricular septal defects in trisomy 21.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preeclampsia and risk of maternal pulmonary hypertension at high altitude in Bolivia.

Journal of developmental origins of health and disease·2023
Same author

Fetal facial bone growth: Post-mortem CT analysis.

Morphologie : bulletin de l'Association des anatomistes·2022
Same author

Optimizing linguistic materials for feature-based intelligibility assessment in speech impairments.

Behavior research methods·2021
Same author

Total Angular Momentum Dichroism of the Terahertz Vortex Beams at the Antiferromagnetic Resonances.

Physical review letters·2021
Same author

Actinomycetoma caused by <i>Gordonia westfalica</i>: first reported case of human infection.

New microbes and new infections·2020
Same author

Datasets acquired with correlative microscopy method for delineation of prior austenite grain boundaries and characterization of prior austenite grain size in a low-alloy high-performance steel.

Data in brief·2019

Area of Science:

  • Cardiovascular Anatomy
  • Fetal Cardiology
  • Genetics

Context:

  • Down syndrome (trisomy 21) is associated with congenital heart defects.
  • Atrioventricular septal defects (AVSDs) are common in trisomy 21.
  • Previous studies identified a minor cardiac anomaly with linear atrioventricular valve insertion in trisomy 21 fetuses.

Purpose:

  • To confirm and expand upon previous findings regarding a minor cardiac anomaly in trisomy 21 fetuses.
  • To investigate the prevalence of linear atrioventricular valve insertion without septal defects in a larger cohort.
  • To propose this anomaly as a potential indicator for trisomy 21.

Summary:

  • A study of 213 trisomy 21 fetal hearts revealed that 62.8% exhibited a linear atrioventricular valve insertion without septal defects, contrasting with 100% normal insertion in controls.

Related Experiment Videos

  • This linear insertion, previously observed only with septal defects, is hypothesized to represent a minor form of the AVSD spectrum.
  • The findings suggest that linear atrioventricular valve insertion without defect is a significant hallmark for trisomy 21, even in the absence of other detectable septal abnormalities.

    • Impact:

    • This research refines the understanding of cardiac anomalies in trisomy 21, expanding the spectrum of atrioventricular septal defects.
    • It highlights the potential of linear atrioventricular valve insertion as a specific marker for trisomy 21 screening during fetal ultrasonography.
    • Accurate identification of this anomaly could improve prenatal diagnosis and management strategies for affected pregnancies.