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Updated: Aug 17, 2026

Probing High-density Functional Protein Microarrays to Detect Protein-protein Interactions
Published on: August 2, 2015
Protein microarrays as a discovery tool for studying protein-protein interactions
1Division of Molecular Genome Analysis (B050), DKFZ Heidelberg, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. U.Korf@DKFZ.de
Abstract:
Exploring the function of the genome and the encoded proteins has emerged as a new and exciting challenge in the postgenomic era. Novel technologies come into view that promise to be valuable for the investigation not only of single proteins, but of entire protein networks. Protein microarrays are the innovative assay platform for highly parallel in vitro studies of protein-protein interactions. Due to their flexibility and multiplexing capacity, protein microarrays benefit basic research, diagnosis and biomedicine. This review provides an overview on the basic principles of protein microarrays and their potential to multiplex protein-protein interaction studies.
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