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High-density electrode array for imaging in vitro electrophysiological activity.

L Berdondini1, P D van der Wal, O Guenat

  • 1Sensors, Actuators and Microsystems Laboratory, Institute of Microtechnology, University of Neuchâtel, Rue Jaquet-Droz 1, CH-2007 Neuchâtel, Switzerland. luca.berdondini@unine.ch

Biosensors & Bioelectronics
|June 22, 2005
PubMed
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Researchers developed a high-density microelectrode array using the Active Pixel Sensor (APS) concept for in vitro electrophysiology. This new device enables high-resolution extracellular recordings of cardiomyocyte activity.

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Electrophysiology

Background:

  • In vitro electrophysiology requires high-resolution tools for detailed cellular activity analysis.
  • Existing microelectrode arrays face limitations in density and addressing capabilities.

Purpose of the Study:

  • To develop and evaluate a novel high-density active microelectrode array for in vitro electrophysiology.
  • To demonstrate the feasibility of the Active Pixel Sensor (APS) concept for advanced extracellular recording.

Main Methods:

  • Fabrication of a 4096-gold microelectrode array (20 microm separation) on a 2.5 mmx2.5 mm chip.
  • Integration of high-speed random addressing logic for sequential pixel selection.
  • Electrical characterization and functional evaluation using neonatal rat cardiomyocyte recordings.

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Main Results:

  • Successful integration of 4096 microelectrodes with 20 microm spacing.
  • Demonstrated high-speed random addressing for selective pixel measurement.
  • Recorded spontaneous cardiomyocyte activity with signal amplitudes ranging from 130 to 300 microVp-p.

Conclusions:

  • The Active Pixel Sensor (APS) concept is suitable for next-generation high-resolution extracellular recording devices.
  • The developed microelectrode array shows promise for advanced in vitro electrophysiology applications.
  • This technology facilitates detailed analysis of cellular electrical activity.