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Updated: Aug 11, 2026
Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique
Published on: October 27, 2011
Fellowship of the rings: the replication of kinetoplast DNA
Beiyu Liu1, Yanan Liu, Shawn A Motyka
1Department of Biological Chemistry, Johns Hopkins Medical School, Baltimore, MD 21205, USA.
Abstract:
Kinetoplastid protozoa such as trypanosomes and Leishmania are important because they cause human disease. These parasites are named after one of their most unusual features, a mitochondrial DNA known as kinetoplast DNA (kDNA). Unlike all other DNA in nature, kDNA comprises a giant network of interlocked DNA rings with a topology resembling that of medieval chain mail. The replication of the kDNA network is more complex than previously thought, and the discovery of new proteins involved in this process is currently the best approach for illuminating the replication mechanism.
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