Related Experiment Video
Updated: Aug 17, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
Antiviral T cell responses: phalanx or multipronged attack?
David N Posnett1, Manuel E Engelhorn, Alan N Houghton
1Department of Medicine, Division of Hematology-Oncology, Weill Medical College, Cornell University, New York, NY 10021, USA. dposnett@mail.med.cornell.edu
Abstract:
Around 700 BCE, a new military formation called the phalanx was established in ancient Greece: a tight column of heavy infantry carrying long spears, or pikes, used in a single prong of attack. Later, in the battle of Marathon described by Herodotus, the Greeks learned the advantages of multipronged attacks, a strategy still used in modern warfare. Is the immune system similar in its approach to combatting pathogens or tumors?
Related Concept Videos
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Cell-mediated Immune Responses
Tumor Immunotherapy
Antiviral Nucleoside Inhibitors
T Cell Activation and Clonal Selection
Naive T cells that have not yet encountered an antigen express two primary CD...
