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Updated: Aug 17, 2026
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
[Relation between the expression of sIL-2R and the relapse in patients with acute lymphoblastic leukemia]
Jin Liu1, Deng-shu Wu, Shen Zhang
1Department of Hematology, Peking University Shenzhen Hospital, Shenzhen 518036, China. liubs6666@tom.com
Objective:
To explore the relation of the serum level of sIL-2R in relapse patients with acute lymphoblastic leukemia (ALL).
Methods:
With ELISA, we determined the levels of sIL-2R of 48 patients with ALL after their first diagnoses, complete remission 1 and relapse. The levels of sIL-2R of 30 patients from complete remission 1 to relapse were monitored.
Results:
The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the control. The levels of sIL-2R were higher in the relapse group and first diagnosed group than in the complete remission 1 group. However, the difference between the complete remission 1 and the control had no statistical significance. When we determined the levels of sIL-2R dynamically, we found that after complete remission, the levels of sIL-2R decreased, however, before one month of hematological relapse, the levels of sIL-2R increased.
Conclusion:
Monitor of the level of sIL-2R can predict impending relapse of patients with ALL and is helpful to early diagnosis of relapse.
