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Recombinant factor VIIa. An update on its clinical use

Massimo Franchini1, Marco Zaffanello, Dino Veneri

  • 1Servizio di Immunoematologia e Trasfusione, Centro Emofilia, Ospedale Policlinico, Piazzale Ludovico Scuro, 37134 Verona, Italy. massimo.franchini@mail.azosp.vr.it

Thrombosis and Haemostasis
|June 22, 2005
PubMed

Recombinant activated factor VII (rFVIIa, NovoSeven) has been successfully used to treat bleeding episodes in patients with antibodies against coagulation factors VIII and IX. In recent years, rFVIIa has also been employed for the management of uncontrolled bleeding in a number of congenital and acquired haemostatic abnormalities. Based on a literature search, this review examines the current knowledge on therapy with rFVIIa, from the now well-standardized uses to the newer and less well-characterised clinical applications.

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