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Updated: Aug 12, 2026

Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
Acquired immunodeficiency syndrome associated lymphoma
Fred E Bertrand1, James A McCubrey
1Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, 600 Moye Blvd., Greenville, NC 27834, USA. bertrandf@mail.ecu.edu
People with HIV have a significantly higher risk of lymphoma. While effective treatments reduce AIDS, lymphoma incidence remains a concern, shifting focus to managing this complication in HIV care.
Area of Science:
- Oncology
- Infectious Diseases
- Immunology
Background:
- Individuals with Human Immunodeficiency Virus (HIV) face a substantially elevated risk of lymphoma, ranging from 150 to 250-fold compared to the general population.
- Highly Active Antiretroviral Therapy (HAART) has decreased Acquired Immunodeficiency Syndrome (AIDS) and opportunistic infections like Kaposi's sarcoma.
- However, HAART has not significantly reduced lymphoma incidence in HIV-positive individuals.
Purpose of the Study:
- To review the association between HIV infection and lymphoma.
- To highlight lymphoma as a growing concern in HIV management.
- To provide an overview of lymphoma etiology and treatment in HIV-positive populations.
Main Methods:
- Literature review of studies on HIV and lymphoma.
- Analysis of epidemiological data on lymphoma incidence in HIV-positive individuals.
- Synthesis of current understanding of HAART's impact on non-AIDS-defining illnesses.
Main Results:
- Lymphoma risk is markedly increased in HIV-positive individuals.
- HAART has not demonstrably lowered lymphoma rates.
- Lymphoma is emerging as a primary comorbidity in the evolving landscape of HIV care.
Conclusions:
- The management of lymphoma is becoming increasingly critical in the care of HIV-positive populations.
- Further research into the etiology and treatment of HIV-associated lymphoma is warranted.
- The shift in HIV morbidity necessitates a focus on non-AIDS-related complications like lymphoma.
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