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Updated: Aug 17, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Transglutaminase and diseases of the central nervous system
Guylaine Hoffner1, Philippe Djian
1UPR 2228 CNRS, Institut Interdisciplinaire des Sciences du Vivant, Université René Descartes, 45, rue des Saints-Pères, 75270 Paris Cedex 06, France.
Abstract:
Alzheimer's disease, Parkinson's disease and diseases of expanded polyglutamine are associated with insoluble protein aggregates and neuronal death. A role for transglutaminase in the stabilization of these aggregates has been proposed. Diseases of polyglutamine expansion have been the most thoroughly investigated and a large body of studies supports the causative role of transglutaminase in aggregation of expanded polyglutamine. However none of the evidence is conclusive. Indisputable evidence of cross-linking by transglutaminase will be required in order to provide firm support for therapeutic measures based on the role of transglutaminase.
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