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Vascularized Composite Hand Allograft Procurement and Preparation for Distal and Proximal Forearm Allotransplantation: A Stepwise Approach
Published on: May 23, 2025
Palmar arch revascularization for arterial occlusion of the distal upper extremity
Renata Weber1, Teresa Benacquista, William Suggs
1Department of Plastic and Reconstructive Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, 1625 Poplar Street, Bronx, NY 10461, USA.
Insights
Upper extremity bypass surgery using saphenous vein grafts effectively treated hand ischemia unresponsive to other methods. This procedure improved pain and healed ulcers in all patients, restoring hand function.
Area of Science:
- Vascular Surgery
- Plastic Surgery
- Hand Surgery
Background:
- Persistent upper extremity ischemia significantly impacts hand function and quality of life.
- Conservative management and endovascular techniques (angioplasty, thrombolysis with tissue plasminogen activator-tPA) may fail to resolve severe hand ischemia.
Purpose of the Study:
- To evaluate the efficacy of upper extremity bypass to the palmar arch for treating hand ischemia refractory to conservative measures.
- To assess the outcomes of using reverse saphenous vein grafts for distal bypass to the palmar arch.
Main Methods:
- Retrospective review of 10 patients (ages 42-66) undergoing upper extremity bypass for hand ischemia.
- Bypass grafts utilized reverse saphenous vein, with distal anastomoses performed to the deep or superficial palmar arch under microscopic magnification.
- Preoperative assessment included angiography, with consideration for angioplasty or tPA.
Main Results:
- All 10 patients experienced improved pain and resolution of tissue ischemia post-surgery.
- Preoperative ulcers healed completely within 3 months in all affected patients.
- No short-term graft failures or complications were reported, with follow-up ranging from 3 months to 3 years.
Conclusions:
- Upper extremity bypass to the palmar arch is a successful treatment for severe hand ischemia.
- Reverse saphenous vein grafts provide durable inflow, and end-to-side palmar arch anastomosis preserves arch continuity and outflow.
- This surgical approach effectively improves healing and alleviates ischemic symptoms in the hand.
Abstract:
During a period of nine years, 10 patients, ages 42 to 66 years (55 +/- 7, mean +/- SD) underwent upper extremity bypass for ischemic changes to the hand not responsive to conservative management. Patients were referred from the vascular department at the authors' institution. Preoperative angiograms were performed and attempts at angioplasty or intravenous attempts to dissolve clots were carried out (with tissue plasminogen activator-tPA) when appropriate. Patients with persistent upper extremity ischemia and an obvious occlusion with reconstitution in the hand were candidates for upper extremity bypass to the palmar arch. All patients had upper extremity bypasses performed with reverse saphenous vein grafts. The proximal anastomoses (end-to-side) were performed by either the vascular or plastic surgery team, while all distal anastomoses (end-to-side) were performed by plastic surgery team microscopic magnification to the deep or superficial palmar arch. Postoperative follow-up ranged from 3 months to 3 years. The bypass graft to the hand resulted in improved pain and resolution of tissue ischemia in all cases. Patients with preoperative ulcers were completely healed by 3 months. The results are in accordance with previous studies demonstrating that improved blood flow afforded by the procedure can improve the healing of recalcitrant ulcers and mitigate the symptoms of ischemic changes. In addition, end-to-side anastomosis to the palmar arch offers significant advantages, in that the continuity of the arch is maintained with all possible outflow vessels, and the problems associated with size discrepancy in the anastomosed vessels are eliminated.
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