Related Experiment Video
Updated: Aug 17, 2026

Experimental Viral Infection in Adult Mosquitoes by Oral Feeding and Microinjection
Published on: July 28, 2022
A prospective epidemiological study to see if mosquito bite could be responsible for spread of hepatitis B virus
1Department of Gastroenterology and Pathology Rajasthan Hospital, Ahmedabad 380 004. mkghoda@yahoo.com
Abstract:
India is a intermediate prevalence zone for hepatitis B virus (HBV) infection. Although mode of transmission of HBV is parenteral, a significant number of patients contract HBV without any such history, the so-called "sporadic" cases. It is postulated that mosquitoes or other arthropods like bedbugs may be involved in transmitting hepatitis B virus (HBV). We hypothesized that, should mosquitoes be responsible for the transmission of HBV, then the incidences of malaria and acute hepatitis due to HBV should show a linkage. We have therefore studied the frequencies of malaria and acute hepatitis B prospectively over three years to see any (a) seasonal changes in the frequencies of the two diseases and (b) any correlation between the seasonal frequencies of two diseases. This study was carried out at Gujrat research and Medical Institute, which is a busy general hospital. Frequencies of malaria and acute hepatitis B were monitored monthly, prospectively over a period of three years. Malaria was clearly a seasonal disease but no distinct peak for acute hepatitis B was documented. Correlation or Linkage between the frequencies of malaria and acute hepatitis B could not be documented to suggest that mosquito bite may be responsible for HBV transmission.
Insights
This study investigated if mosquitoes transmit the hepatitis B virus (HBV). Researchers found no correlation between malaria and acute hepatitis B seasonality, suggesting mosquitoes are unlikely HBV vectors.
Area of Science:
- Hepatology
- Infectious Diseases
- Medical Entomology
Background:
- Hepatitis B virus (HBV) infection is prevalent in India, with many sporadic cases lacking a clear transmission history.
- Arthropods, such as mosquitoes and bedbugs, are hypothesized as potential vectors for HBV transmission.
Purpose of the Study:
- To investigate the potential role of mosquitoes in HBV transmission.
- To examine the correlation between the seasonal incidence of malaria and acute hepatitis B.
Main Methods:
- Prospective monthly monitoring of malaria and acute hepatitis B frequencies over three years.
- Analysis of seasonal patterns and correlation between the two diseases.
Main Results:
- Malaria exhibited a distinct seasonal pattern.
- No clear seasonal peak for acute hepatitis B was observed.
- No significant correlation was found between the seasonal frequencies of malaria and acute hepatitis B.
Conclusions:
- The study did not find evidence to support mosquitoes as vectors for HBV transmission.
- Further research may be needed to identify the transmission routes of sporadic HBV cases.
Related Concept Videos
Hepatitis
Yellow Fever
Viral Hepatitis I: Introduction
Arboviral Encephalitis
Transmission of Pathogens

