A prospective epidemiological study to see if mosquito bite could be responsible for spread of hepatitis B virus

Manoj K Ghoda1, Ramesh A Shah

  • 1Department of Gastroenterology and Pathology Rajasthan Hospital, Ahmedabad 380 004. mkghoda@yahoo.com

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|June 25, 2005
PubMed

Insights

This study investigated if mosquitoes transmit the hepatitis B virus (HBV). Researchers found no correlation between malaria and acute hepatitis B seasonality, suggesting mosquitoes are unlikely HBV vectors.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Medical Entomology

Background:

  • Hepatitis B virus (HBV) infection is prevalent in India, with many sporadic cases lacking a clear transmission history.
  • Arthropods, such as mosquitoes and bedbugs, are hypothesized as potential vectors for HBV transmission.

Purpose of the Study:

  • To investigate the potential role of mosquitoes in HBV transmission.
  • To examine the correlation between the seasonal incidence of malaria and acute hepatitis B.

Main Methods:

  • Prospective monthly monitoring of malaria and acute hepatitis B frequencies over three years.
  • Analysis of seasonal patterns and correlation between the two diseases.

Main Results:

  • Malaria exhibited a distinct seasonal pattern.
  • No clear seasonal peak for acute hepatitis B was observed.
  • No significant correlation was found between the seasonal frequencies of malaria and acute hepatitis B.

Conclusions:

  • The study did not find evidence to support mosquitoes as vectors for HBV transmission.
  • Further research may be needed to identify the transmission routes of sporadic HBV cases.

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
Transmission of Pathogens01:24

Transmission of Pathogens

Pathogens spread from their reservoirs to susceptible hosts through three main routes: contact transmission, vehicle transmission, and vector transmission. Each route involves distinct mechanisms of transfer.Contact TransmissionThis category includes direct contact, indirect contact, and droplet transmission:Direct contact involves immediate physical interaction between individuals—such as a handshake—which can spread pathogens like Streptococcus pyogenes, the bacterium responsible for...