Related Experiment Video

Updated: Aug 17, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
07:27

Implantation of Total Artificial Heart in Congenital Heart Disease

Published on: July 18, 2014

Stroke as a complication of congenital heart disease

Ji Y Chong1, Shunichi Homma, J P Mohr

  • 1Doris and Stanley Tananbaum Stroke Center, Neurological Institute, Columbia University Medical Center, New York, NY 10032, USA.

Current Atherosclerosis Reports
|June 25, 2005
PubMed

Insights

Patent foramen ovale is common but may not increase recurrent stroke risk in medically treated patients. Current evidence does not support surgical or device closure for stroke prevention.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Devices

Background:

  • Patent foramen ovale (PFO) is a frequent condition in the general population.
  • PFO is linked to a higher risk of stroke.
  • Optimal secondary stroke prevention strategies for patients with PFO remain debated.

Purpose of the Study:

  • To review the current understanding of PFO's role in stroke.
  • To evaluate evidence for different treatment modalities for stroke prevention in PFO patients.
  • To address the ongoing questions regarding the best therapeutic approaches.

Main Methods:

  • Review of existing clinical trial data.
  • Analysis of studies comparing anticoagulation versus antiplatelet therapy.
  • Assessment of evidence for interventional closure procedures.

Main Results:

  • Antiplatelet therapy is supported by some data for secondary stroke prevention.
  • Medical management may mitigate the increased stroke risk associated with PFO.
  • Insufficient data exists to recommend surgical or percutaneous PFO closure for stroke prevention.

Conclusions:

  • Antiplatelet therapy appears beneficial for secondary stroke prevention in patients with PFO.
  • The role of PFO closure in stroke prevention requires further investigation.
  • Current evidence favors medical management over procedural closure for PFO-associated stroke risk.

More Related Videos

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Mouse Heterotopic Cervical Cardiac Transplantation Utilizing Vascular Cuffs08:44

Mouse Heterotopic Cervical Cardiac Transplantation Utilizing Vascular Cuffs

Published on: June 23, 2022

Related Concept Videos

Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...