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HDL dysfunction in obstructive sleep apnea.

Kathryn C B Tan1, Wing-Sun Chow, Jamie C M Lam

  • 1Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China. kcbtan@hkucc.hku.hk

Atherosclerosis
|June 25, 2005
PubMed
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High-density lipoprotein (HDL) is dysfunctional in obstructive sleep apnea (OSA) patients, contributing to increased cardiovascular risk. This dysfunction impairs HDL

Area of Science:

  • Cardiovascular Science
  • Sleep Medicine
  • Lipid Metabolism

Background:

  • High-density lipoprotein (HDL) possesses anti-atherogenic and antioxidant properties.
  • HDL dysfunction is observed in coronary heart disease and may be implicated in obstructive sleep apnea (OSA).
  • OSA is associated with elevated oxidative stress.

Purpose of the Study:

  • To investigate HDL function in patients with obstructive sleep apnea (OSA).
  • To determine if HDL exhibits dysfunction in OSA, potentially contributing to cardiovascular risk.

Main Methods:

  • Recruited 128 OSA patients and 82 controls.
  • Assessed HDL dysfunction by measuring its ability to inhibit LDL oxidation ex vivo.
  • Quantified plasma levels of oxidized LDL and 8-isoprostane.

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Main Results:

  • OSA subjects exhibited elevated plasma 8-isoprostane levels.
  • Despite similar lipid profiles, OSA patients showed significantly greater HDL dysfunction and increased oxidized LDL.
  • Apnea-hypopnea index was the primary determinant of HDL dysfunction in OSA.

Conclusions:

  • HDL is dysfunctional in OSA, impairing its ability to prevent oxidized lipid formation and inactivation.
  • This HDL dysfunction may contribute to the heightened cardiovascular risk observed in OSA patients.