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Updated: Aug 17, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Expression pattern of adaptor protein PAG: correlation between secondary lymphatic follicle and histogenetically
Alexandr Svec1, Zuzana Velenská, Václav Horejsí
1Department of Pathology, Faculty Hospital Královske Vinohrady and 3rd Faculty of Medicine, Charles University, Srobarova 50, Prague 10, Czech Republic.
Abstract:
Transmembrane adaptor protein PAG, also known as Csk-binding protein (Cbp), which binds and activates the cytoplasmic tyrosine kinase Csk, the major negative regulator of Src-family kinases, was found to be expressed in germinal centers of lymphoid follicles as well as in follicular, but not mantle cell lymphomas. Expression of PAG may reflect its role in regulation of proliferation and differentiation of germinal center B-cells. From the routine histopathology point of view, PAG might be a new positive marker of follicular lymphoma and a negative marker of mantle cell lymphoma.
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