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Updated: Oct 2, 2026
10:49
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 19, 2013
[Recent results in the field of vinblastine group antitumour alkaloids. Biochemical studies]
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1979
Abstract:
Studies on the interaction between vinblastine-like alkaloids and their receptor, i.e. tubulin, are reported. They shed some light on the structure-activity relationships in this medicinally important series: the configuration at C14' and C16', as well as the presence of the methoxycarbonyl group on C16' seem to play an essential role in the determination of biological activity. A new analogue, detected by its specific behaviour with tubulin, was found, in vivo, to be as active and less toxic than vinblastine.
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