[An in vivo OCT study of human natural accommodation in a 19-year-old albino]

Modifications of the anterior segment during accommodation of the eye under examination cannot be studied in a simple and direct way with anterior segment imaging techniques such as Scheimpflug photography, A Scan, B Scan, and UBM. With this equipment, it is necessary to stimulate the fellow eye in order to observe the variations of the analyzed eye. The techniques using ultrasound equipment can only be used with contact systems or with water baths that will modify the anatomical dimensions or the pressure of the anterior segment. With the Scheimpflug photographic technique, geometrical reconstructions are necessary and cannot be used in certain axes. Optical coherence tomography provides the advantage of producing non-contact images of the anterior segment in static and dynamic conditions that are then easy to use. The target of the optical system can be focused and unfocused with negative or positive lenses, thus reproducing the conditions of natural accommodation. With a normal subject, the morphological modifications of the crystalline lens behind the iris screen cannot be studied because the infrared light source used is blocked by the pigment epithelium. The absence of this pigment in an albino subject allowed us to study the modifications of the crystalline lens and the ciliary body during accommodation. In this study, we were able to definitely confirm all the modifications of the anterior segment as described by von Helmholtz in 1855, who, at the time, used very rudimentary optical procedures based on the reflections of a flame on the surface of the crystalline lens.