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Related Experiment Videos

New odourless protocols for efficient Pauson-Khand annulations.

Jack A Brown1, Stephanie Irvine, William J Kerr

  • 1WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, UKG1 1XL.

Organic & Biomolecular Chemistry
|June 25, 2005
PubMed
Summary

Dodecyl methyl sulfide effectively promotes the Pauson-Khand cyclisation reaction. This inexpensive additive provides good to excellent yields of cyclopentenone products for various substrates.

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Area of Science:

  • Organic Chemistry
  • Synthetic Chemistry
  • Catalysis

Background:

  • The Pauson-Khand reaction is a vital method for synthesizing cyclopentenones.
  • Developing efficient promoters for this reaction is crucial for synthetic applications.

Purpose of the Study:

  • To investigate the efficacy of dodecyl methyl sulfide as a promoter in the Pauson-Khand cyclisation.
  • To evaluate the yield and applicability of this promoter with different substrates.

Main Methods:

  • Utilizing dodecyl methyl sulfide as an additive in the Pauson-Khand cyclisation.
  • Testing the reaction with both intramolecular and intermolecular substrates.

Main Results:

  • Dodecyl methyl sulfide demonstrated high effectiveness as a promoter.

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  • The reaction afforded good to excellent yields of desired cyclopentenone products.
  • The additive is inexpensive and commercially available.

    • Conclusions:

    • Dodecyl methyl sulfide is a highly effective and economical promoter for the Pauson-Khand cyclisation.
    • This finding offers a valuable tool for the synthesis of cyclopentenones.