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Related Experiment Videos

Intranasal trigeminal sensitivity in subjects with allergic rhinitis.

H Doerfler1, T Hummel, L Klimek

  • 1Department of Gastroenterology, University of Erlangen-Nürnberg Medical School, Krankenhausstrasse 12, 91054 Erlangen, Germany.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|June 25, 2005
PubMed
Summary

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Allergic rhinitis alters trigeminal nerve sensitivity. Allergen exposure shortened chemo-somatosensory event-related potential (ERP) latencies, correlating with symptom severity, suggesting ERPs may predict allergic responses.

Area of Science:

  • Neuroscience
  • Immunology
  • Otorhinolaryngology

Background:

  • Trigeminal nerve endings in the nasal mucosa respond to various stimuli.
  • Chemo-somatosensory event-related potentials (ERPs) quantify trigeminal nerve activation.
  • Allergic rhinitis involves inflammation and altered sensory perception in the nasal cavity.

Purpose of the Study:

  • To investigate changes in trigeminal nerve responsiveness to intranasal stimulation in allergic rhinitis patients.
  • To determine if allergen exposure affects chemo-somatosensory ERPs.
  • To correlate ERP changes with reported rhinitis symptoms.

Main Methods:

  • 13 subjects with allergic rhinitis underwent intranasal CO(2) stimulation in three sessions: baseline, after NaCl, and after allergen.

Related Experiment Videos

  • Chemo-somatosensory ERPs were recorded.
  • Subjects rated rhinitis symptom intensity.

    • Main Results:

    • Allergen administration significantly shortened P1 and N1 peak latencies of chemo-somatosensory ERPs.
    • ERP latency changes correlated with reported rhinitis symptom intensity.
    • A negative relationship was observed between general symptom score and ERP latencies.

    Conclusions:

    • Allergen-induced nasal itching and sneezing in allergic rhinitis are linked to trigeminal nerve activation via local inflammation.
    • Chemo-somatosensory ERP latencies may predict subject responsiveness to allergens.
    • ERPs offer a quantifiable measure of trigeminal nerve involvement in allergic rhinitis.