Related Experiment Video
Updated: Aug 17, 2026
Effects of Desmodium caudatum on Gastrointestinal Hormones and Intestinal Flora in Rats with Gastritis
Published on: March 1, 2024
[Changes of somatostatin (SS) in stomach and duodenum of rats after +Gz exposure]
Xue-jun Zhong1, Zhan-jun Wu, Yan-ping Sun
1Department of Gastroenterology, Jinan Shangdong, China.
Objective:
To study effects of +Gz exposure on the change of somatostatin (SS) in stomach and duodenum of rats.
Method:
Forty male Wistar rats were randomly divided into +1 Gz control group, +5 Gz x 5 min group, +10 Gz x 5 min group and repeated exposure [(+5 Gz x 2 min) + (+10 Gz x 2 min) + (+5 Gz x 2 min)] group. After +Gz exposure, the rats in each group were anesthesized by aether, and gastric and duodenal mucosa were taken immediately. Levels of SS were assayed using radioimmunoassay (RIA) methods.
Results:
Gastric and duodenal mucosa of the control group and +5 Gz group were intact and smooth. Under naked eye and light microscope, scattered hemorrhagic spoto, small ulcers, submucosal hyperemia, and erosion of mucosa were found in gastric antrum and duodenum in +10 Gz group rats. Diffuse hyperemia, erosion and small ulcers were found in mucosa of gastric fundus, gastric antrum and duodenum of repeated exposure group. Exposure to +Gz can increase somatostatin content in gastric antrum and duodenum (P<0.01).
Conclusion:
Increase of SS content may play an important role in the prevention of pathogenesis of stomach and duodenum after +G exposure.
