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Related Experiment Videos

Electric fields in bone marrow substructures at power-line frequencies.

Roanna S Chiu1, Maria A Stuchly

  • 1Department of Electrical and Computer Engineering, University of Victoria, Victoria, BC V8W 3P6, Canada.

IEEE Transactions on Bio-Medical Engineering
|June 28, 2005
PubMed
Summary

Electromagnetic fields from power lines may impact bone marrow cells. Numerical models show electric fields can cause significant transmembrane potential changes, suggesting a potential link to childhood leukemia.

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Area of Science:

  • Biophysics
  • Computational Biology
  • Environmental Health

Background:

  • Leukemia originates in bone marrow.
  • The relationship between electromagnetic fields (EMFs) and childhood leukemia is under investigation.
  • Subcellular effects of EMF exposure require further study.

Purpose of the Study:

  • To investigate the subcellular effects of power-line frequency electromagnetic fields on bone marrow.
  • To model bone marrow substructures exposed to electric fields numerically.
  • To assess the biological significance of electric field-induced changes in bone marrow cells.

Main Methods:

  • Numerical computation using the finite element method (FEM) and scalar potential finite difference method.
  • Modeling of cancellous bone structures using computed tomography scan data.

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  • FEM implementation for bone marrow stroma cells with thin film approximation.

    • Main Results:

    • A maximum electric field enhancement of 50% was observed in bone marrow substructures.
    • Transmembrane potential (TMP) changes in bone marrow stroma cells ranged from several to over 200 microV.
    • Calculations suggest biologically significant TMP changes can occur.

    Conclusions:

    • Numerical models indicate electric fields can induce significant transmembrane potential changes in bone marrow cells.
    • These findings suggest a potential subcellular mechanism linking EMF exposure to leukemia.
    • Further research is warranted to explore the implications for childhood leukemia.