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Y-chromosome STR haplotypes in Sweden
Gunilla Holmlund1, Helena Nilsson, Andreas Karlsson
1The National Board of Forensic Medicine, Department of Forensic Genetics, University Hospital, SE-581 85 Linköping, Sweden. gunilla.holmlund@rmv.se
Forensic Science International
|June 28, 2005
Summary
This study analyzed Y-chromosome STR haplotypes in 708 Swedish men, revealing high genetic diversity. A specific haplotype was identified as significantly Swedish, offering insights into population genetics.
Area of Science:
- Genetics
- Population Genetics
- Forensic Science
Background:
- Understanding Y-chromosome STR (short tandem repeat) marker diversity is crucial for population genetics and forensic applications.
- Previous studies have established Y-chromosome STR profiles for various European populations, but detailed Swedish data were limited.
Purpose of the Study:
- To establish a Y-chromosome STR haplotype reference database for Swedish men.
- To assess the genetic diversity within the Swedish population using specific Y-chromosome STR markers.
- To identify unique or characteristic haplotypes for the Swedish population.
Main Methods:
- Typing of 708 Swedish men for eight Y-chromosome STR markers (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, and DYS385).
- Analysis of PCR (polymerase chain reaction) products using ABI377 with sequenced allelic ladders.
- Haplotype diversity calculation and frequency analysis.
Main Results:
- A total of 423 different Y-chromosome haplotypes were identified among the 708 individuals.
- The overall haplotype diversity was high, calculated at 0.994.
- A specific haplotype (14, 12, 28, 23, 10, 11, 13, 14-14) occurred with the highest frequency (5.79%) and was found to be significantly distinct compared to other European populations.
Conclusions:
- The Y-chromosome STR analysis reveals substantial genetic diversity within the Swedish male population.
- The identified high-frequency haplotype provides a potential genetic marker for Swedish ancestry.
- This dataset serves as a valuable resource for forensic investigations and anthropological studies in Sweden.