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Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal

G Chételat1, B Landeau, F Eustache

  • 1Inserm E0218-Université de Caen, Laboratoire de Neuropsychologie, Centre Cyceron, Bd. H. Becquerel, BP 5229, 14074 Caen cedex, France. chetelat@cyceron.fr

Neuroimage
|June 28, 2005
PubMed
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This study tracked gray matter loss in mild cognitive impairment (MCI) patients, finding accelerated atrophy in converters to Alzheimer's disease (AD) in key brain regions like the hippocampus.

Area of Science:

  • Neuroimaging
  • Neurology
  • Alzheimer's Disease Research

Background:

  • Mild cognitive impairment (MCI) is a precursor to Alzheimer's disease (AD).
  • Understanding gray matter (GM) atrophy dynamics in MCI is crucial for predicting AD conversion.
  • Longitudinal studies are needed to map disease progression.

Purpose of the Study:

  • To longitudinally map GM loss in MCI patients.
  • To compare GM atrophy patterns between MCI converters and non-converters.
  • To identify brain regions most affected during conversion to probable AD.

Main Methods:

  • Prospective study of 18 amnestic MCI patients over 18 months.
  • High-resolution T1-weighted MRI scans at baseline and follow-up.
  • Novel longitudinal voxel-based morphometry (VBM) to assess GM changes.

Related Experiment Videos

Main Results:

  • Seven of 18 MCI patients converted to probable AD.
  • Converters showed lower baseline GM in hippocampus and parahippocampal cortex.
  • Accelerated GM loss in converters observed in hippocampus, temporal gyrus, posterior cingulate, and precuneus.

Conclusions:

  • Longitudinal VBM effectively maps GM changes in MCI.
  • Accelerated atrophy in specific regions in converters suggests distinct pathological processes.
  • This approach aids understanding of AD progression and treatment monitoring.