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DIAL: a web-based server for the automatic identification of structural domains in proteins
Ganesan Pugalenthi1, Govindaraju Archunan, Ramanathan Sowdhamini
1National Centre for Biological Sciences, Tata Institute of Fundamental Research UAS-GKVK campus, Bellary Road, Bangalore 560 065, Karnataka, India.
Nucleic Acids Research
|June 28, 2005
Summary
DIAL is a web server that automatically identifies protein structural domains from 3D coordinates. This aids in understanding protein function, designing experiments, and identifying related protein families.
Area of Science:
- Structural biology
- Bioinformatics
- Computational biology
Background:
- Identifying structural domains is crucial for understanding protein function and evolution.
- Accurate domain delineation aids in experimental design and identifying distantly related protein families.
Purpose of the Study:
- To present DIAL, a web server for automatic protein structural domain identification.
- To provide a tool for analyzing protein structures, including multiple chains and domain swapping.
Main Methods:
- The DIAL web server utilizes algorithms to analyze protein 3D coordinates.
- It automatically identifies and delineates structural domains within protein structures.
Main Results:
- DIAL successfully identifies structural domains and their boundaries.
- The server can analyze crystallographic multiple chains and detect domain swapping events.
Conclusions:
- DIAL offers an automated approach to protein domain identification.
- This tool facilitates deeper insights into protein structure-function relationships and evolutionary connections.