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Updated: Jul 19, 2026
14:49
Associated Chromosome Trap for Identifying Long-range DNA Interactions
Published on: April 23, 2011
Multiple alignment of genomic sequences using CHAOS, DIALIGN and ABC
Dirk Pöhler1, Nadine Werner, Rasmus Steinkamp
1Institute of Microbiology and Genetics, University of Göttingen, Goldschmidtstr. 1, 37077 Göttingen, Germany.
Nucleic Acids Research
|June 28, 2005
Summary
This study introduces a WWW-based system for multiple genomic sequence alignment. It uses CHAOS and DIALIGN tools for rapid analysis and ABC for visualization, aiding functional site discovery.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomics
Background:
- Comparative genomic sequence analysis is crucial for identifying functional sites.
- Existing methods may require efficient tools for large-scale genomic data.
Purpose of the Study:
- To present a novel WWW-based software system for multiple alignment of genomic sequences.
- To enhance the speed and efficiency of genomic sequence alignment and visualization.
Main Methods:
- Utilized the CHAOS local alignment tool to identify pairwise similarities as anchor points.
- Integrated CHAOS with the DIALIGN multiple-alignment program for accelerated processing.
- Employed the ABC visualization tool for interactive graphical representation of alignments.
Main Results:
- Developed a functional WWW-based software system for genomic sequence multiple alignment.
- Demonstrated a method to speed up multiple alignment using local similarity chains.
- Provided interactive visualization of multiple sequence alignments.
Conclusions:
- The presented system offers an efficient approach for multiple genomic sequence alignment.
- This tool facilitates the discovery of functional sites through comparative genomics.
- The software is accessible via the Göttingen Bioinformatics Compute Server (GOBICS).
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