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[An experimental study on proliferative effects and apoptotic effects of podophyllic acid in K562 cells]
Jian Yu1, Che Chen, Peilong Gao
1The Affiliated First Hospital of Lanzhou University, Lanzhou 730000.
Objective:
To study the effects of podophyllic acid on proliferation and apoptosis in human leukemia K562 cells.
Methods:
The inhibitory effects of podophyllic acid on K562 cells were investigated by clony-formation and MTT colorimetric assay. The apoptotic effects were observed by FCM.
Results:
Podophylic acid could inhibit the proliferation of K562 cells and there were a significant difference between experimental and control groups (P < 0.01). There was a marked positive correlation between drug concentration and the inhibitory rates. Podophyllic acid could induce apoptosis of K562 cells. When K562 cells were treated with 5.0 microg/ml podophyllic acid for 48 hours, apoptosis occurred to the largest extent. The apoptosis rate of podophyllic acid was 33.5%.
Conclusions:
Podophyllic acid has antitumor effect, but the change of structure affects the function of derivatives of podophylloxin greatly.
