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Two cases of cutaneous cryptococcosis
1Department of Dermatology, 3rd Hospital, Hangzhou, China. xiaxiujiao@hz.cn
Mycoses
|June 29, 2005
Summary
Two male patients developed cutaneous cryptococcosis, a fungal infection, without prior health issues. Both cases resolved with antifungal treatment, highlighting Cryptococcus neoformans as a cause of skin lesions.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Cutaneous cryptococcosis is a rare fungal infection typically seen in immunocompromised individuals.
- This report details two cases in immunocompetent male patients, expanding the understanding of its presentation and risk factors.
Observation:
- Case 1 presented with a neck mass that ulcerated post-surgery, revealing Cryptococcus neoformans with characteristic encapsulated spores.
- Case 2 exhibited a thigh nodule caused by C. neoformans, with a slight reduction in CD4+ cells.
Findings:
- Both patients achieved mycological and clinical cure following appropriate antifungal therapy (amphotericin B, fluconazole, itraconazole).
- The causative isolates were identified as Cryptococcus neoformans var. gattii serotype C and Cryptococcus neoformans var. grubii serotype A.
Implications:
- These cases underscore that cutaneous cryptococcosis can occur in immunocompetent individuals.
- Early diagnosis and targeted antifungal treatment are crucial for successful outcomes in cutaneous cryptococcosis.