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Updated: Aug 17, 2026

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Published on: September 6, 2017
Four new HLA class I alleles in Cauacasoids
M Alonso-Nieto1, F García-Sánchez, R Lillo
1Laboratory of Histocompatibility, Regional Transfusion Center, Madrid, Spain.
Abstract:
Four new HLA classical class I alleles in the three loci are described in Caucasian individuals. A*3012 was first suspected by an abnormal serologic pattern that would be explained by the single amino acid substitution at the A30-specific Ser17. B*270505 differs from B*270502 in a silent substitution at an up to now constant position in the B locus. B*3541 encodes for a new Cys at position 118 that has not been encountered in neither human nor primate alleles. Cw*0716 seems to be originated by a large-scale interallelic recombination event between Cw*0701/*0706/*0718 and Cw*020202, giving rise to a new antigen-binding cleft conformation.
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