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Related Experiment Videos

What does the PANSS mean?

Stefan Leucht1, John M Kane, Werner Kissling

  • 1Klinik für Psychiatrie und Psychotherapie der TU-München Klinikum rechts der Isar, Ismaningerstr. 22, 81675 München, Germany. Stefan.Leucht@lrz.tum.de

Schizophrenia Research
|June 29, 2005
PubMed
Summary
This summary is machine-generated.

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The Positive and Negative Syndrome Scale (PANSS) total score has unclear clinical meaning. A 50% reduction in PANSS scores better defines treatment response in schizophrenia trials, though 25% may suffice for resistant cases.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • The Positive and Negative Syndrome Scale (PANSS) is widely used to assess schizophrenia symptoms.
  • The clinical interpretation of PANSS total scores and response thresholds (e.g., 20% or 50% reduction) remains unclear.
  • Simultaneous assessment with the Clinical Global Impressions (CGI) scale can provide a more interpretable framework.

Purpose of the Study:

  • To clarify the clinical meaning of PANSS total scores.
  • To establish the relationship between PANSS scores and CGI ratings.
  • To evaluate the appropriateness of different PANSS score reduction cut-offs for defining treatment response.

Main Methods:

  • A pooled database of 4091 patients from seven antipsychotic drug trials (olanzapine or amisulpride) was analyzed.

Related Experiment Videos

  • PANSS and CGI ratings were collected at baseline and at weeks 1, 2, 4, and 6.
  • Equipercentile linking was used to compare PANSS and CGI scores.

    • Main Results:

    • Specific PANSS total scores corresponded to CGI severity ratings: "mildly ill" (58), "moderately ill" (75), "markedly ill" (95), and "severely ill" (116).
    • A "minimally improved" CGI rating correlated with PANSS reductions of 19-28% over six weeks.
    • A "much improved" CGI rating correlated with PANSS reductions of 40-53% over six weeks.

    Conclusions:

    • The study provides a framework for interpreting PANSS total scores in acute schizophrenia exacerbation trials.
    • A PANSS reduction of at least 50% is recommended to define treatment response in typical trials.
    • A 25% PANSS reduction cut-off may be suitable for treatment-resistant schizophrenia populations.