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Updated: Aug 17, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
Published on: July 30, 2015
Contrasting models of promiscuous gene expression by thymic epithelium
Geoffrey O Gillard1, Andrew G Farr
1Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.
Abstract:
Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model-whereby TRA expression is regulated by conserved developmental programs active in developing mTECs-may be equally plausible.
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