Electroanalytical study of fluvoxamine

Area of Science:

• Electrochemistry
• Analytical Chemistry
• Pharmaceutical Analysis

Background:

• Fluvoxamine (FVX) is an important pharmaceutical compound.
• Accurate quantification of FVX is crucial for quality control and therapeutic monitoring.
• Existing analytical methods may have limitations in terms of speed or cost.

Purpose of the Study:

• To develop and validate electrochemical methods for the quantification of Fluvoxamine (FVX).
• To assess the applicability of these methods in pharmaceutical formulations and biological matrices like human serum.
• To evaluate a flow-injection analysis (FIA) system coupled with SWAdSV for high-throughput analysis.

Main Methods:

• Square-wave adsorptive-stripping voltammetry (SWAdSV) using a mercury-drop electrode at pH 2.
• Sample analysis in batch mode for pharmaceutical products and spiked human serum.
• Development and implementation of a flow-injection analysis (FIA) system with SWAdSV detection.

Main Results:

• Fluvoxamine (FVX) exhibited a distinct reduction peak at -0.7 V vs. Ag/AgCl.
• Successful quantification of FVX in a pharmaceutical product was achieved.
• Recoveries of FVX in spiked human serum ranged from 76% to 89%.
• The FIA-SWAdSV method demonstrated high sample throughput (up to 120 samples/hour) and was not significantly affected by dissolved oxygen.

Conclusions:

• Validated SWAdSV methods provide accurate quantification of Fluvoxamine (FVX).
• The developed FIA-SWAdSV system offers a rapid, cost-effective alternative to chromatographic methods for FVX analysis.
• These electrochemical techniques show promise for routine analysis of Fluvoxamine (FVX) in various matrices.