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Predictors of coronary artery disease in the Lebanese population

Antoine Abchee1, Houry Puzantian, Sami T Azar

  • 1Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Thrombosis Research
|June 30, 2005
PubMed

Insights

Elevated serum lipoprotein (a) [Lp(a)] and fasting blood glucose (FBG) are key predictors of coronary artery disease (CAD) in Lebanese patients. These factors, along with age and hypertension, are crucial for CAD risk assessment and prevention strategies.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Biomarkers in Disease

Background:

  • Coronary artery disease (CAD) is a leading global cause of death.
  • Identified risk factors include age, gender, diabetes, dyslipidemia, smoking, and elevated serum levels of lipoprotein (a) [Lp(a)], homocysteine, C-reactive protein [CRP], and uric acid.

Purpose of the Study:

  • To evaluate the association of biologic and metabolic parameters with CAD in a Lebanese patient cohort.
  • To identify independent predictors of CAD within this population.

Main Methods:

  • Recruited 300 patients for the study.
  • Measured biologic and blood metabolic parameters.
  • Categorized patients into control (0% stenosis), <50% stenosis, and >=50% stenosis groups based on catheterization results.

Main Results:

  • Hyperlipidemias, CRP, homocysteine, and uric acid levels did not differ significantly between CAD patients and controls.
  • Age, elevated fasting blood glucose [FBG], and elevated serum Lp(a) levels were identified as strong independent predictors of CAD.
  • Gender, hypertension, diabetes, and family history of CAD also showed an association with CAD.

Conclusions:

  • Serum Lp(a) levels and FBG are important for predicting and preventing CAD in the studied population.
  • Highlights the significance of these biomarkers for cardiovascular risk management.
Abstract

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