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Updated: Jul 8, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
[The normoxic therapeutic compression effect on microcirculation in acute stroke]
Hyperbaric therapy, or normoxic therapeutic compression, shows significant benefits for acute ischemic stroke patients. This treatment enhances tissue respiration and restores microcirculation, offering a stable therapeutic effect without increasing blood plasma oxygenation.
Area of Science:
- Neurology
- Hyperbaric Medicine
- Cardiovascular Research
Background:
- Acute ischemic stroke poses a significant health challenge.
- Conventional treatments have limitations in restoring neurological function.
- Hyperbaric oxygen therapy is explored for its potential therapeutic effects.
Purpose of the Study:
- To evaluate the efficacy of two hyperbaric therapeutic regimes (1.5 atm and 1.2 atm) in patients with acute ischemic stroke.
- To investigate the impact of barotherapy on acid-base equilibrium, platelet aggregation, and lipid peroxidation.
- To compare barotherapy's effects with conventional treatment methods.
Main Methods:
- Patients with acute ischemic stroke were treated with two different hyperbaric regimes (1.5 atm and 1.2 atm).
- Analysis included acid-base equilibrium dynamics in capillary and venous blood, whole blood, and plasma.
- Investigated parameters were platelet aggregation and lipid peroxidation.
Main Results:
- Barotherapy demonstrated a marked therapeutic effect compared to conventional methods in stroke patients.
- Unlike other oxygen therapies, barotherapy did not result in blood plasma hyperoxygenation or increased lipid peroxidation.
- Activation of tissue respiration, normalization of lipid peroxidation, and restoration of CO2 resources were observed.
Conclusions:
- Barotherapy provides a stable therapeutic effect in brain ischemia by activating tissue respiration and restoring microcirculation.
- Normoxic therapeutic compression offers a distinct advantage over other oxygen therapies.
- The method promotes renewal of microcirculation and autoregulation, leading to improved outcomes in acute ischemic stroke.
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