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[Vascular symptoms of Behcet's disease]
Insights
Vascular symptoms, primarily venous thrombosis, affect approximately one-quarter of Behcet
Area of Science:
- Rheumatology
- Vascular Medicine
- Immunology
Context:
- Behcet's disease (BD) is a multisystemic inflammatory disorder with potential vascular manifestations.
- Understanding the spectrum and incidence of vascular complications is crucial for patient management.
- This study focuses on patients treated at the Institute of Rheumatology over a 10-year period.
Purpose:
- To characterize the vascular symptoms observed in patients with Behcet's disease.
- To determine the incidence and types of vascular complications in a cohort of BD patients.
- To investigate associations between vascular disorders and patient demographics or disease characteristics.
Summary:
- Vascular complications were identified in 24.5% of 151 Behcet's disease patients.
- Venous thrombosis was the most common manifestation (36 patients), followed by arterial lesions in four males.
- Vascular disorders were associated with younger age and earlier thrombotic complications in males compared to females.
Impact:
- Provides insights into the prevalence and nature of vascular involvement in Behcet's disease.
- Highlights the predominance of venous thrombosis and specific arterial lesions.
- Suggests demographic factors influencing vascular complication development in BD patients.
Aim:
To characterize vascular symptoms of Behcet's disease (BD) in patients treated for the last 10 years in the Institute of Rheumatology.
Material And Methods:
Vascular symptoms of BD were studied in 151 patients with BD (mean age 33.5 +/- 9.5 years, duration of the disease 14.0 +/- 10.1 years, 104 males and 47 females, 67.4% carried HLA B51(5) antigen). Duplex vascular scanning was made to detect venous thrombosis.
Results:
Thrombotic complications were found in 37 of 151 (24.5%) patients with BD (30 males and 7 females, mean age 37.1 +/- 9.1 years, mean duration of the disease 7.3 +/- 9.7 years). Venous thromboses prevailed (36 patients). Four males (2.6%) had arterial lesions: aneurysms of the iliac arteries (n = 1), thrombosis of the iliac artery (n = 1), pulmonary infarction and thrombosis of the pulmonary arteries (n = 2). Combination of venous and arterial manifestations occurred in 3 patients. One patient had thrombosis of the venous sinus, occlusion of the retinal vessels was diagnosed in 7 patients.
Conclusion:
Incidence of vascular disorders was observed in 1/4 of the patients. This corresponds to those observed worldwide and concerns venous thrombosis and other thromboses. Among the examinees, vascular disorders were associated with a young age, earlier development of thrombotic complications in males than in females.
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