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Splenic marginal zone cell lymphoma.

C Schmid1, N Kirkham, T Diss

  • 1Department of Histopathology, University College & Middlesex School of Medicine, London, England.

The American Journal of Surgical Pathology
|May 1, 1992
PubMed
Summary
This summary is machine-generated.

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This study details four female patients diagnosed with primary splenic low-grade non-Hodgkin

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Splenic marginal zone lymphoma is a rare B-cell neoplasm.
  • Primary splenic involvement is uncommon, often presenting with non-specific symptoms.

Purpose of the Study:

  • To describe the clinicopathologic features of primary splenic low-grade non-Hodgkin's B-cell lymphomas.
  • To evaluate the treatment outcomes in these patients.

Main Methods:

  • Case series describing four female patients.
  • Histopathological and immunophenotypic analysis of spleen, bone marrow, lymph nodes, and liver.
  • Clinical follow-up of patients post-splenectomy and chemotherapy.

Main Results:

  • All patients presented with splenomegaly, anemia, and weight loss.

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  • Bone marrow involvement was universal; liver and lymph node involvement occurred in some cases.
  • Splenectomy alone resulted in good outcomes for three patients; one patient receiving chemotherapy died.

    • Conclusions:

    • Primary splenic low-grade non-Hodgkin's B-cell lymphoma is a distinct entity.
    • Splenectomy appears to be an effective initial treatment for this condition.