Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrenal cortex -- the next biological clock?

Marek Pawlikowski1

  • 1Department of Experimental Endocrinology and Hormone Diagnostics, Chair of Endocrinology, Medical University of Lodz, Lodz, Poland. pawlikowski.m@wp.pl

Neuro Endocrinology Letters
|July 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Screen-printed flexible carbon electrodes for efficient neural impulse transmission.

Scientific reports·2025
Same author

Corrigendum to "The role of mathematical models in prediction of osteoarthritis development" [Comput. Biol. Med. 193 (2025) 110407].

Computers in biology and medicine·2025
Same author

The role of mathematical models in prediction of osteoarthritis development.

Computers in biology and medicine·2025
Same author

Innovative approach in the treatment of comminuted proximal phalanx fractures in horses based on biomechanical modelling.

Scientific reports·2025
Same author

Selection of density standard and X-ray tube settings for computed digital absorptiometry in horses using the k-means clustering algorithm.

BMC veterinary research·2025
Same author

A novel, patient-tailored method for non-invasive iFRCT measurement.

Cardiology journal·2024
Same journal

IL-6 and TNFα are associated with depressive symptoms among men in a community-based cohort, with a tentative trend for IL-17A: Findings from the Shika Study in Japan.

Neuro endocrinology letters·2026
Same journal

Information and communication technologies and social media in nursing practice: From the perspective of nurses and patients.

Neuro endocrinology letters·2026
Same journal

Hematological Profiles in Women with Lipedema: Exploratory Analysis of Platelet Distribution Width and Mean Platelet Volume. .

Neuro endocrinology letters·2026
Same journal

The Association Between Handgrip Strength and Type 2 Diabetes Mellitus in Community Dwelling Older Adults in Nanjing, China.

Neuro endocrinology letters·2026
Same journal

Toxic masculinity and depression in men: A schema therapy perspective.

Neuro endocrinology letters·2026
Same journal

Impact of Helicobacter pylori- and Porphyromonas gingivalis-associated metabolic syndrome on local and systemic disorders.

Neuro endocrinology letters·2026
See all related articles

Aging leads to adrenal zona reticularis atrophy and dehydroepiandrosterone (DHEA) decline. This age-related hormonal deficiency may stem from reduced cell proliferation and increased apoptosis in the zona reticularis.

Area of Science:

  • Endocrinology
  • Aging Biology
  • Cell Biology

Background:

  • Plasma dehydroepiandrosterone (DHEA) levels peak in the third decade and decline with age.
  • DHEA deficiency is linked to age-related functional disturbances.
  • The adrenal zona reticularis (ZR), responsible for DHEA secretion, undergoes atrophy during aging.

Purpose of the Study:

  • To propose a mechanism for age-related zona reticularis atrophy.
  • To explain the decline in DHEA levels associated with aging.

Main Methods:

  • Analysis of adrenal cortex cell kinetics.
  • Comparison of proliferation and apoptotic indices across adrenal cortex zones.
  • Hypothesizing cell migration and differentiation pathways.

Related Experiment Videos

Main Results:

  • The zona reticularis exhibits the lowest cell proliferation and highest apoptotic indices in the adrenal cortex.
  • Adrenocortical cells are hypothesized to originate from progenitor cells and migrate inward.
  • The zona reticularis contains the oldest adrenocortical cells, potentially reaching their replicative limit (Hayflick's number).

Conclusions:

  • Age-related zona reticularis atrophy results from a preponderance of apoptosis over proliferation.
  • This atrophy leads to a decline in DHEA secretion, contributing to aging-related functional changes.