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Updated: Aug 17, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
The surgical management of femoral osteolysis
1Department of Orthopaedic Surgery, Stanford University Medical Center, Room R-109, Edwards Building, 300 Pasteur Drive, Stanford, CA 94305-5335, USA.
Abstract:
Fifteen patients underwent reoperation for failed total hip arthroplasty. At surgery, patients who had proximal femoral osteolysis with osseointegrated femoral components were managed with lesional treatment that included debridement and bone grafting. The femoral components included 7 extensively coated stems, 5 proximally coated stems, and 3 modular femoral components. At a minimum 5-year follow-up evaluation, all 15 femoral components remained radiographically stable. Graft material in contained defects appeared to consolidate radiographically. For selected patients, debridement and grafting of femoral osteolytic defects provide satisfactory intermediate term outcomes.
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