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Updated: Aug 17, 2026

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
[Present chemoprevention and future vision]
Isabel Filges1, Khalil Zaman, Olivier Michielin
1Fondation du centre pluridisciplinaire d'oncologie, CHUV, 1011 Lausanne. Isabel.Filges@hospvd.ch
Abstract:
Cancer chemoprevention is defined as the use of natural or synthetic agents to reverse, suppress or prevent carcinogenic progression to invasive cancer. The success of several clinical trials within high-risk patients suggests that chemoprevention is a rational and promising strategy. This review will resume the principal molecular mechanisms of chemoprevention and discuss results and clinical outcome of selected clinical trials. The difficulties in clinical application and future directions will be highlighted.
Insights
Cancer chemoprevention uses agents to prevent cancer progression. Clinical trials show it
Area of Science:
- Oncology
- Molecular Biology
- Preventive Medicine
Context:
- Cancer chemoprevention is a promising strategy for high-risk individuals.
- It involves using natural or synthetic agents to halt cancer development.
Purpose:
- To review the molecular mechanisms of cancer chemoprevention.
- To discuss clinical trial outcomes and challenges.
- To highlight future research directions.
Summary:
- Chemoprevention agents can reverse, suppress, or prevent carcinogenic progression.
- Successful clinical trials in high-risk populations validate this approach.
- This review covers mechanisms, trial results, and clinical applications.
Impact:
- Provides insights into effective cancer prevention strategies.
- Informs clinical practice and future research in oncology.
- Highlights the potential of chemoprevention in reducing cancer incidence and mortality.
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