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Updated: Aug 17, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
[New systemic therapies in oncology]
Khalil Zaman1, Nicholas Ketterer, Diane Vulliémoz
1Fondation du Centre pluridisciplinaire d'oncologie, CHUV, 1011 Lausanne. Khalil.Zaman@hospvd.ch
Abstract:
These last decades showed important progress in cancer systemic therapies. A better understanding of the differences between cancer cells and normal cells lead to the emergence of targeted therapies. These treatments interfere with different specific molecules playing a critical role in tumour growth or progression. On the other side, thanks to the development of new therapeutic substances, new modes of administration and to the improvement of supportive care, conventional chemotherapy is more effective and less toxic. The following review summarizes current progress with clinical impact observed these last years.
Insights
Recent decades have seen major advances in cancer systemic therapies, including targeted treatments and improved conventional chemotherapy, leading to better outcomes and reduced toxicity for patients.
Area of Science:
- Oncology
- Cancer Biology
- Pharmacology
Context:
- Significant advancements in understanding cancer cell biology and molecular pathways.
- Evolution of systemic cancer treatments over the past decades.
- Improvements in drug development, administration, and supportive care.
Purpose:
- To review recent progress in cancer systemic therapies.
- To highlight clinical impacts of novel and improved treatments.
- To provide an overview of targeted therapies and enhanced chemotherapy.
Summary:
- Targeted therapies have emerged by exploiting differences between cancer and normal cells, interfering with critical tumor growth molecules.
- Conventional chemotherapy has become more effective and less toxic due to new substances, administration methods, and supportive care.
- The review synthesizes recent clinical findings and progress in systemic cancer treatment.
Impact:
- Demonstrates the clinical impact of recent progress in cancer systemic therapies.
- Highlights the effectiveness and reduced toxicity of modern cancer treatments.
- Provides insights into the evolving landscape of oncology therapeutics.
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