Related Experiment Video

Updated: Jul 13, 2026

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

American Association for Cancer Research 1999: 10-14 April, Philadelphia, Pennsylvania

F Lavelle1

  • 1Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, 94403 Vitry -sur-Seine Cedex, France.

Expert Opinion on Investigational Drugs
|July 5, 2005
PubMed

Insights

This research consolidates data on known cancer therapies, including farnesyl transferase inhibitors and novel tyrosine kinase inhibitors targeting angiogenesis. Clinical potential of these signal transduction inhibitors requires further long-term evaluation.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Background:

  • Consolidation of data on known therapeutic approaches and compounds.
  • Focus on signal transduction inhibitors for cancer treatment.
  • Evaluation of farnesyl transferase inhibitors and tyrosine protein kinases inhibitors.

Purpose of the Study:

  • To present Phase I clinical trial results for farnesyl transferase inhibitors.
  • To discuss preclinical data on new tyrosine protein kinases inhibitors targeting angiogenesis.
  • To explore novel topoisomerase and antimitotic agents.

Main Methods:

  • Phase I clinical trials of farnesyl transferase inhibitors (R 115777, L 778,123).
  • Preclinical evaluation of tyrosine protein kinases inhibitors (EGF-R, CDKs, VEGF-R).
  • Assessment of quinazoline, indolinone, and pyrido-pyrimidine chemical series.

Main Results:

  • Phase I results for R 115777 and L 778,123 presented.
  • Convincing in vivo antitumour activity observed for quinazolines, indolinones, and pyrido-pyrimidines.
  • New compounds ZD 1490, PD 183805, PD 166285, SU 6668, GW 5181 identified.

Conclusions:

  • Phase I results contribute to the clinical use debate of signal transduction inhibitors.
  • Full clinical potential of these compounds will require years to ascertain.
  • Several novel inhibitors show promise for cancer therapy, including angiogenesis and antimitotic agents.

More Related Videos

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells08:46

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

Published on: November 12, 2019

In Vitro Assay to Study Tumor-macrophage Interaction08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...