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Updated: Jul 13, 2026
14:14
Adaptation of Semiautomated Circulating Tumor Cell (CTC) Assays for Clinical and Preclinical Research Applications
Published on: February 28, 2014
American Association for Cancer Research 1999: 10-14 April, Philadelphia, Pennsylvania
1Rhône-Poulenc Rorer, Centre de Recherche de Vitry-Alfortville, 94403 Vitry -sur-Seine Cedex, France.
Expert Opinion on Investigational Drugs
|July 5, 2005
Summary
This research consolidates data on known cancer therapies, including farnesyl transferase inhibitors and novel tyrosine kinase inhibitors targeting angiogenesis. Clinical potential of these signal transduction inhibitors requires further long-term evaluation.
Area of Science:
- Oncology
- Pharmacology
- Clinical Trials
Background:
- Consolidation of data on known therapeutic approaches and compounds.
- Focus on signal transduction inhibitors for cancer treatment.
- Evaluation of farnesyl transferase inhibitors and tyrosine protein kinases inhibitors.
Purpose of the Study:
- To present Phase I clinical trial results for farnesyl transferase inhibitors.
- To discuss preclinical data on new tyrosine protein kinases inhibitors targeting angiogenesis.
- To explore novel topoisomerase and antimitotic agents.
Main Methods:
- Phase I clinical trials of farnesyl transferase inhibitors (R 115777, L 778,123).
- Preclinical evaluation of tyrosine protein kinases inhibitors (EGF-R, CDKs, VEGF-R).
- Assessment of quinazoline, indolinone, and pyrido-pyrimidine chemical series.
Main Results:
- Phase I results for R 115777 and L 778,123 presented.
- Convincing in vivo antitumour activity observed for quinazolines, indolinones, and pyrido-pyrimidines.
- New compounds ZD 1490, PD 183805, PD 166285, SU 6668, GW 5181 identified.
Conclusions:
- Phase I results contribute to the clinical use debate of signal transduction inhibitors.
- Full clinical potential of these compounds will require years to ascertain.
- Several novel inhibitors show promise for cancer therapy, including angiogenesis and antimitotic agents.
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