Related Experiment Video
Updated: Aug 7, 2026

Technique to Collect Fungiform (Taste) Papillae from Human Tongue
Published on: September 18, 2010
The oral mucosal punch biopsy. A report of 140 cases
1Dermatology Associates, Cincinnati, Ohio.
Background:
Dermatologists are often confronted with neoplasms and diseases of the oral cavity. Although many may be reluctant to perform oral surgical procedures, a biopsy is often needed to establish a definitive diagnosis. This article describes a simple and safe method of obtaining an oral biopsy specimen.
Observations:
A punch was used in performing 140 biopsies from various locations of the oral cavity. Bleeding was controlled by pressure in the majority of cases, with only a few requiring electrodesiccation. Biopsy sites, all of which were left to heal by secondary intention, showed almost complete reepithelialization at a 2-week postoperative check. Complications from surgery were almost nonexistent and minor in degree.
Conclusions:
The punch biopsy of the oral cavity is a safe and useful technique that can be easily employed by dermatologists. Biopsies should be kept superficial, and neurovascular structures must be avoided to prevent complications.
More Related Videos
05:42Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
Published on: August 11, 2023
05:05Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025