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Synthesis and DNA-binding affinities of monomodified berberines
Ji-Yan Pang1, Yong Qin, Wen-Hua Chen
1School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.
Abstract:
Four new monomodified berberines have been synthesized in moderate to good yields starting from berberine and fully characterized by HRMS and 1H NMR. Spectrometric titration and ethidium bromide displacement experiments indicate that these berberine derivatives, especially the one having primary amino group, strongly bind with calf-thymus DNA, presumably via an intercalation mechanism.
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