Related Experiment Video
Updated: Aug 17, 2026

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
Published on: February 20, 2017
New bicyclic taxane diterpenoids from Taxus sumatrana
Ya-Ching Shen1, Shaw-Man Hsu, Yun-Sheng Lin
1Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Abstract:
Investigation of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of two new bicyclic taxoids, tasumatrols M (1), and N (2) and a new baccatin III derivative, tasumatrol O (3) together with the previous known 7-deacetylcanadensene (4) and 2alpha,7beta,13alpha-triacetoxy-5alpha,9alpha-dihydroxy-2(3-->20) abeotaxa-4(20),11-dien-10-one. The structures of these taxanes were established on the basis of spectroscopic analyses, especially 1- and 2D NMR, and chemical derivatization.
Related Concept Videos
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

